The narrative begins with the colony’s struggles, inadequately prepared for the challenges of the unfamiliar and harsh environment. Facing resource shortages, John White, the colony’s leader, is compelled to return to England for essential supplies. Yet, unforeseen circumstances and geopolitical tensions delay his return for an unexpected two years.

Upon his return, White is met with an eerie sight: the colony site is deserted, with no trace of its inhabitants. Dr. Powell delves into the haunting mysteries that have shrouded this historical event for centuries. Central to the tale is White’s instruction to the colonists to seek refuge “Fifty Miles Into the Main” in case of confrontations with hostile natives or Spanish forces.